A Blueprint for an International Cancer Epigenome Consortium. A Report from the AACR Cancer Epigenome Task Force

Recent whole-genome sequencing of thousands of human cancers has uncovered an unexpectedly large number of mutations in genes, which control the epigenome. Many of these recurrent mutations are in epigenetic writers (e.g., EZH2, DNMT3a), readers (BRD4-NUT fusions), erasers (UTX mutations), and