This paper proposes a novel high-step-up DC-DC power converter for high output-voltage applications from a low level of input voltage. The presented power converter is composed of a integrated boost-flyback converter with two output windings plus cascaded voltage doublers to boost up the 12 V input voltage to a high DC voltage level of 400 V. Description of the presented DC-DC power conversion circuit, and experimental results of a prototype converter for providing 40W output power with a 12V input DC voltage are demonstrated.