Assignment of the gene for β-spectrin (SPTB) to chromosome 14q23→q24.2 by in situ hybridization

Type I hereditary spherocytosis results from a molecular defect in the β-polypeptide of the erythrocyte cytoskeletal protein spectrin. Using a cDNA probe, we had previously assigned the gene for human erythrocyte β-spectrin (SPTB) to chromosome 14 based upon analysis of its segregation in panels of human × rodent somatic cell hybrids (Winkelmann et al., 1988). Here we report the regional localization of this gene by in situ hybridization to 14q23→q24.2.