自愈水凝胶
壳聚糖
化学
药物输送
凝聚
毒品携带者
右旋糖酐
十二烷基硫酸钠
控制释放
靶向给药
氧化铁纳米粒子
色谱法
氧化铁
材料科学
纳米技术
高分子化学
生物化学
有机化学
作者
Mohammad Reza Saboktakin,Roya M. Tabatabaie,Abel Maharramov,М. А. Рамазанов
标识
DOI:10.1016/j.carbpol.2010.02.034
摘要
The purpose of this study was to examine chitosan (CS)–dextran sulfate (DS) nanoparticles coated iron oxide as drug carriers detectable using magnetic resonance imaging (MRI) technique. The 5-aminosalicylic acid (5-ASA) was chosen as model drug molecule. CS–DS hydrogels were formulated by a complex coacervation process under mild conditions. The influence of process variables, including the two ionic polymers, on particle size, and hydrogel entrapment of 5-ASA was studied. The in vitro release of 5-ASA were also evaluated, and the integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The release of 5-ASA from hydrogel was based on the ion-exchange mechanism. The CS–DS hydrogel developed based on the modulation of ratio show promise as a system for controlled delivery of drug detectable using magnetic resonance imaging (MRI) technique.
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