This paper studied the effects of Colla Corri Asini effervescent granules on hematopoietic function and anti-fatigue in mice.The anemia mouse model induced by phenylhydrazine hydrochloride was used to detect the effect of Colla Corri Asini effervescent granules on erythrocyte and haemoglobin.The weight loading swimming experiment,liver index and liver glycogen content were used to detect the effect of Colla Corri Asini effervescent granules on anti-fatigue.The results showed that the E-jiao effervescent granules could make the haemoglobin and erythrocyte of the posthemorrhagic anemia mice increase obviously,which had a very significant difference compared with the blank control group;different doses of E-jiao effervescent granules could increase the swimming time,which had a significant difference compared with the blank control group;it could also increase the liver index and liver glycogen with different content.These indicated that E-jiao effervescent granules has the curative effect in anemia mice,it also has a enhancement effect of anti-fitigue of mice.