Effects of Baizhu Fuling Tang with Raw Atractylodes macrocephala or Processed A. macrocephala on Spleen Disorder due to Dampness Model Rats

OBJECTIVE:To study the effects of Baizhu fuling tang with raw Atractylodes macrocephala or processed A. macrocephala on control disorder due to dampness model rats. METHODS:Spleen disorder due to dampness model was established. 50 SD rats were divided into normal control group(constant volume of normal saline),model group(constant volume of normal saline),Baisu fuling tang group(raw A. macrocephala,8 g/kg),Baizhu fuling tang group(processed A. macrocephala,8 g/kg)and Pingwei powder group(8 g/kg). Body weight,abdominal perimeter,leg perimeter,average food-intake and the amount of drinking water were all determined;the activity of Na+-K+-ATP enzyme was detected;the contents of NT,SP and VIP were measured. RESULTS:Compared with normal control group,body weight of rats decreased significantly in model group,while abdominal perimeter and leg perimeter increased significantly;average food-intake and the amount of drinking water decreased significantly;there was statistical significance(P0.05);the activity of Na+-K+-ATP enzyme and SP content in serum decreased significantly,while the contents of NT and VIP increased significantly;there was statistical significance(P0.05). Compared with model group,body weight,average food-intake and the amount of drinking water of rats in Baizhu fuling tang group(raw A. macrocephala)increased significantly, while abdominal perimeter decreased significantly; there was statistical significance(P0.05). The activity of Na+-K+-ATPase in serum increased significantly,while the contents of NT and VIP decreased significantly;there was statistical significance(P0.05). CONCLUSIONS:Baizhu fuling tang with raw A. macrocephala is better than that with processed A. macrocephala in the treatment of spleen disorder due to dampness. Its mechanism may be associated with the secretion regulation of Na+-K+-ATP enzyme,NT,SP and VIP. Raw A. macrocephala in Baisu fuling tang can not be replaced by processed A. macrocephala.