A Case-Control Study of Ambulatory Blood Pressure to Guide Medication Time Adjustment for Patient with Resistant Hypertension

Objective To study blood pressure compliance status of patients with resistant hypertension to guide medication time adjustment by ambulatory blood pressure.Methods All 116patients were randomly divided into ambulatory blood pressure group(group A),bedtime medicine group(group B)and morning medicine group(group C).Ambulatory blood pressure parameters were observed with ambulatory blood pressure monitoring(ABPM)before medication adjustment and four weeks after treatment.Results In group A,24hmean systolic blood pressure(24h-MSBP),24hmean diastolic blood pressure(24h-MDBP),24hmean arterial pressure(24hMAP),daytime average systolic blood pressure(d-SBP),night mean diastolic blood pressure(n-SBP),night average diastolic blood pressure(n-DBP),night mean arterial pressure(n-MAP)and blood pressure load of patients were significantly improved and blood pressure load of patients using antihypertensive drugs with the onset time less than4hours were significantly improved(P0.01).Patients using antihypertensive drugs(the onset time4hours)or long-acting antihypertensive drugs(Half-life24hours)in group A and group B are better than group C.Conclusion Medication time adjustment guided by ambulatory blood pressure can significantly improve blood pressure compliance status for patients with resistant hypertension.