Effect of PR expression on sensitivity of chemotherapy with TC regimen in locally advanced breast cancer

Objective To investigate the effect of PR expression on the sensitivity of chemotherapy with TC regimen in locally advanced breast cancer patients.Methods The expression of PR was detected by EnVision immunohistochemistry in breast cancer tissues before neoadjuvant chemotherapy with TC regimen in corresponding patients,and the correlation of PR expression with the sensitivity of chemotherapy were studied in 57 PR negative or positive patients.Results The sensitivity was 81.48%(22/27)in PR negative breast tumours,and was 53.33%(16/30) in PR positive breast tumours with TC regimen in locally advanced breast cancer patients,and there was significant difference of sensitivity between breast cancer patients with PR negative and positive tumours(P0.05).Conclusion PR negative breast cancer patients were more sensitive to neoadjuvant chemotherapy.PR negative may serve as one of good markers for prediction of sensitivity of neoadjuvant chemotherapy with TC regimen in locally advanced breast cancer patients.