Asymmetric Addition of Phenylacetylene and Benzaldehyde Catalyzed by Chiral 1,1'-Bi-2-naphthol Derivatives

Chiral 3,3′-substituted 1,1′-bi-2-napthol(BINOL) derivatives were synthesized from BINOL. The asymmetric addition of phenylacetylene and benzaldehyde in the presence of the BINOL derivative and diethyl zinc afforded the corresponding propargylic alcohols with 73% yield and 40% enatiomeric excess.