Advances in antibody-dependent enhancement for dengue virus

Antibody-dependent enhancement(ADE) present in the infection of dengue virus(DENV) has huge effect on the effect of treatment.ADE of virus replication is believed to occur when heterotypic,nonneutralizing antibody present in the host from a previous DENV infection binds to the virus via binding to the Fcγ receptors(FcγR) during a subsequent heterotypic infection but is unable to neutralize the virus.The overall result is an increase in virus replication and the level of viremia,which is associated with an increase in disease severity.Studies on the immune response of ADE can contribute to the derelopment of effective vaccines and drugs.In this review,the resent advances of ADE in dengue virus are discussed.