Anti-tumor effect of curcuma aramatica oil on murine colorectal adenocarcinoma

Objective: To investigate the the anti-tumor effect with curcuma aramatica oil in adenocarcinoma and mechanism in mice. Methods: The inhibiting effect was detected by MTT. The model of colorectal adenocarcinoma was established in mice. Comparative analysis between control and experimental groups on the survival of mice and the growth of tumor. Apoptosis of adenocarcinoma cells was evaluated by the method of TUNEL. Results: Curcuma aramatica oil inhibited the growth of CT26 cells significantly in vivo concerntration dependent. The growth of tumor was suppressed by curcuma aramatica oil (P0.05).The average survival time was far longer than control group(P0.05). The index of apoptosis (AI) was singnificantly higher than that of conrol group(P0.05).Conclusion: Curcuma aramatica oil can induce the anti-tumor effect, perhaps promoting apoptosis is the main mechanism.