Objective:To obtain a further understanding of the clinical manifestations and relative factors of antibiotic associated diarrhea in cerebrovascular patients.Methods:To retrospectively analyze the antibiotics usage status in 29 examples of antibiotic associated diarrhea in the department of neurology in our hospital from Jan.2005 to May 2009.Results:The duration and severity of diarrhea depended on the age,complicated disease of patient, changing antibiotics frequently or combining to use antibiotic,invasive manipulation, using cathartic before diarrhea.The more serious disorders of consciousness and the more frequently changing antibiotics,the longer diarrhea will last.Conclusion:The incidence and severity of antibiotic associated diarrhea can be reduced by using antibiotic more rationally. Rational treatment may reduce the duration of diarrhea.