Interventional effect of danshaohuaxian on the level of SOD and MDA from the lung tissues in rats with fibrosis pulmonary

Objective:To observe the interventional effect of Danshaohuaxian(DSH) on the level of SOD and MDA from the lung tissues in rats with fibrosis pulmonary.Methods:Thirty Spague-Dawley rats were randomly divided into the control group,model group and treatment group.The model group and the treatment group were induced pulmonary fibrosis with bleomycin(5 mg/kg)endotracheally,while the control group was given with normal saline instead.From the second day of injection,the rats in the treatment group were administered intragastricly with DSH(0.8 g/kg/d).while the other rats were given normal saline instead.All rats were sacrificed on the twenty-eighth day,Histopathologicalhy examination,the lung coefficient,lung droxyproline(Hyp),SOD and MDA content was observed.Results:①Compared with NC group,it was revealed that the rats lung coefficient and lung tissue Hyp were significantly increased and the degree of pulmonary alveoli inflammation and pulmonary fibrosis was significantly induced in the PF group,the rats lung tissue SOD were significantly decreased,and the MDA were significantly increased.②Comparedwith PF group,it was revealed that the rats lung coefficient and lung tissue Hyp were significantly decreased and the degree of pulmonary alveoli inflammation and pulmonary fibrosis was significantly relieved in the DSHC group,the rats lung tissue SOD were significantly increased and the MDA were significantly decreased.Conclusion:DSH has a good action against experimental pulmonary fibrosis which may be to elevate the activity of lung tissue SOD to alleviate oxidative stress.