医学
肺癌
表皮生长因子受体
内科学
肿瘤科
酪氨酸激酶
肺
癌症
受体
作者
Yu‐Mu Chen,Chia-Yun Lai,Kun‐Ming Rau,Cheng-Hua Huang,Huang‐Chih Chang,Tung‐Ying Chao,Chia‐Cheng Tseng,Wen‐Feng Fang,Yung‐Che Chen,Yoon Kyu Chung,Yi‐Hsi Wang,Mu-Chun Su,Kuo‐Tung Huang,Shih-Feng Liu,Hung-Chen Chen,Yu‐Ling Chang,Yu-Ping Chang,Chin‐Chou Wang
出处
期刊:Lung Cancer
[Elsevier]
日期:2016-08-01
卷期号:98: 99-105
被引量:13
标识
DOI:10.1016/j.lungcan.2016.05.020
摘要
Objectives The clinical characteristics and survival of very young (≤40 years) and very old ( > 80 years) patients with advanced non-small cell lung cancer (NSCLC) are distinct. However, the benefits of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) to patients at the extremes of age with NSCLC harboring EGFR mutation have not been well studied. We retrospectively studied the effect of extreme age on patients’ clinical characteristics and prognosis. Materials and methods Of 1510 lung cancer patients diagnosed between November 2010 and March 2014, 555 patients who were tested for EGFR mutations were included. Patients were divided into the following groups according to age: young (≤40 years), lower medium (41–60 years), higher medium (61–80 years), and very old (>80 years). Results Of the 555 patients, 20 (3.6%) patients were aged ≤40 years and 60 (10.8%) patients were aged >80 years. Young NSCLC patients had a lower BMI (p = 0.003), more brain (p = 0.016) and bone metastases (p = 0.002) Very young lung cancer patients still have poor prognosis even they were EGFR mutant. (EGFR mutant vs. wild type patients, OS: 12 vs. 7.3 months, p = 0.215) Very old NSCLC patients had a lower BMI (p = 0.003) and poor ECOG PS (p = 0.028). Positive EGFR mutation test reverses poor prognosis of elderly NSCLC patients. (EGFR mutant vs. wild type patients, OS: 13.2 vs. 4.9 months, p = 0.003) Conclusion We observed EGFR mutations reverse the poor prognosis of old patients with NSCLC. However, young patients with lung cancer have a poor prognosis even if they harbor EGFR mutations.
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