Objective:To evaluate the value of combined application of enhanced scanning of both MSCT and MRI in differential diagnosis between pancreatic cancer and chronic pancreatitis.Materials and Methods:Enhanced scanning images of both MSCT and MRI of pancreatic cancer in 31 cases and chronic pancreatitis in 25 cases were analyzed retrospectively.The image features of both pancreatic cancer and chronic pancreatitis were sumerized,and the differences of image features between pancreatic cancer and chronic pancreatitis were stated.The differences in differential diagnosis between Pancreatic Cancer and Chronic Pancreatitis by MSCT,MRI respectively,or both MSCT and MRI were also stated.Results:Volume of tumor,infiltration into blood vessel or tissue nearby,intumescent lymph node,scarcely-enhanced mode of tumor and irregular distention of chol-pancreatic duct were relative to pancreatic cancer.Cyst in tumor or nearby,calcification in tumor and smooth distention of chol-pancreatic duct were relative to chronic pancreatitis.There were significant differences in the signals above between pancreatic cancer and chronic pancreatitis(P0.05).The accuracy in distinguishing pancreatic cancer from chronic pancreatitis by both MSCT and MRI was higher than that by MSCT or MRI respectively(P0.05).There were not differnces in diagnosing pancreatic cancer from chronic pancreatitis either by MSCT or by MRI(P0.05).Conclusion:It was useful to distinguish pancreatic cancer from chronic pancreatitis by combined application of enhanced scanning of both MSCT and MRI.