In this review, considering the problems existing in wastewater treatment plants using fix-time strategy, the feasibilities of dissolved oxygen (DO), oxidation-reduction potential (ORP) and pH value used as real-time control parameters were analyzed according to the reaction mechanism of wastewater bio-treatment. The results showed that the changes of DO, ORP and pH could indirectly express the situation of COD, N and P removal during wastewater treatment. So theoretically, the DO, ORP and pH used as real-time control parameters could control wastewater treatment process. On the basis of this, the application of DO, ORP and pH as real-time control parameters in wastewater treatment is summarized, and the problems in this research fields were reviewed.This paper points out that the applied fundamental research of real-time control in wastewater treatment should be strengthened and this process should be combined with intelligent control in order to make wastewater treatment automatized. Ref 27