Advances of the Research on Molecular Biochemistry Study of Pheochromocytoma and Paraganglioma

About 10% of the pheochromocytomas and paragangliomas belong to inherited causes. These causes may be multiple endocrine neoplasia type 2(MEN2), von Hippel-Lindau disease(VHL), neurofibromatosis (NF), inherited paraganglioma and inherited pheochromocytoma. Up till now, RET gene, VHL gene, and SDHx gene have been known to get involved in the tumorigenesis of the pheochromocytoma and paraganglioma. In this article we introduce the studies of these genes.