Tripterygium wilfordii is a traditional Chinese herb,with immunological regulation and anti-inflammatory effects.Tripterygium wilfordii and its derivate have been reported to show efficacy in patients with a variety of inflammatory and autoimmune diseases,including rheumatic disease,autoimmune disorder,organ transplant,nephronia,asthma,tumor,and so on.Here, we give a review of the immunological regulating Effects of Tripterygium wilfordii.