1-磷酸鞘氨醇
鞘氨醇-1-磷酸受体
鞘氨醇
受体
细胞生物学
化学
S1PR1型
鞘氨醇激酶
鞘脂
信号转导
脂质信号
生物
G蛋白偶联受体
磷酸化
作者
Qian Li,Yi Li,Cai Lei,Ying Tan,Guang-Hui Yi
标识
DOI:10.1016/j.cca.2021.03.025
摘要
Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates a series of physiological and pathological processes via binding to five S1P receptors (S1PR1-5). Although S1PR1-3 are widely expressed, the study of S1PRs, however, mainly addressed S1PR1 and S1PR2, and few studies focus on S1PR3-5. In recent years, a growing number of studies have shown that S1PR3 plays an important role in cell proliferation, differentiation, apoptosis, and migration, but its function is still controversial. This is the first comprehensive review paper about the role of S1PR3 signaling in cardiovascular function, tissue fibrosis, cancer, immune response, and neurological function. In addition, existing S1PR3 agonists and antagonists are listed at the end of the article, and we also put forward our opinion on the dispute of S1PR3 function.
科研通智能强力驱动
Strongly Powered by AbleSci AI