Cardamonin inhibits osteogenic differentiation of human valve interstitial cells and ameliorates aortic valve calcification via interfering in the NF-κB/NLRP3 inflammasome pathway

Cardamonin (CDM) is a natural chalcone with strong anti-inflammatory properties. CDM ameliorates aortic valve calcification by inhibiting the phenotypical calcific transformation of hVICs via mediating the inactivation of the NF-κB/NLRP3 inflammasome.