牙周炎
炎症
硫化氢
脂多糖
发病机制
胱硫醚γ裂解酶
内生
刺激
体外
医学
免疫学
细胞生物学
化学
胱硫醚β合酶
生物
酶
生物化学
内科学
有机化学
硫黄
半胱氨酸
作者
Xuesong Lu,Hanchuang Zhu,Yi Chen,Yue Wu,Dongsheng Zhang,Baocun Zhu,Shengyun Huang
标识
DOI:10.1038/s41598-021-99761-4
摘要
Periodontitis, one of the most common chronic inflammatory diseases, affects the quality of life. Osteogenesis plays an important role in the disease. There is a connection between hydrogen sulfide (H2S) and periodontitis, but according to the study has been published, the precise role of H2S in inflammation remains in doubt. The main reason for the lack of research is that H2S is an endogenous gasotransmitter, difficult to discern through testing. So, we synthesized a novel fluorescence probe which can detect H2S in vitro. By using the novel H2S fluorescence probe, we found that H2S changes in osteoblasts mainly by cystathionine-γ-lyase, and H2S increases under LPS stimulation. H2S could be a potential marker for diagnosis of inflammatory diseases of bone, and might help deepen studies of the changes of H2S level and promote the progression on the researches about pathogenesis of periodontitis.
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