In Vivo X‐ray Triggered Catalysis of H2 Generation for Cancer Synergistic Gas Radiotherapy

To date, hydrogen (H₂ ) therapy has received widespread attention. However, X-ray triggered sustainable H₂ -producing materials with controlled release for cancer treatment have not been reported. Herein, an X-ray triggered sustainable in situ H₂ producing platform, Au NR-TiO₂ @ZnS:Cu,Co-A(Au-TiO₂ @ZnS), composed of Au-amorphous TiO₂ nano-dumbbell-shaped heterostructure coated with long afterglow particles, was developed for cancer synergistic H₂ -radiotherapy. The mechanism of H₂ production was verified by theoretical calculations and in vitro experiments. Changes in the apoptosis pathway caused by the synergistic effect of H₂ and radiotherapy were reported. Guided by its excellent photoacoustic imaging capabilities, mice with orthotopic liver cancer achieved excellent therapeutic effects and low inflammatory side effects, suggesting that Au-TiO₂ @ZnS has promising application potential for cancer treatment and prognosis.