Insights From Matrix Metalloproteinase-2 Genotypes to Decipher the Genetic Architecture of Bladder Cancer Risk

BACKGROUND/AIM: gene, rs243865 and rs2285053, with BLCA susceptibility in a Taiwanese population. PATIENTS AND METHODS: A case-control study was conducted involving 375 BLCA patients and 375 cancer-free controls matched by age and sex. Genotyping was performed using PCR-RFLP, and associations with BLCA risk were evaluated using logistic regression, adjusting for confounders. Stratified analyses were performed based on demographic and clinical parameters. RESULTS: =0.0001). CONCLUSION: rs2285053 and, to a lesser extent, rs243865 polymorphisms may influence BLCA susceptibility and aggressiveness, particularly in the context of age and smoking. These variants may serve as potential biomarkers for personalized risk assessment, pending validation in larger, multiethnic cohorts.