Myricetin-functionalized Prussian blue nanoparticles enable multi-modal therapy against methicillin-resistant Staphylococcus aureus and accelerate wound repair

, M@HPBA with irradiation achieves high antibacterial efficiency against MRSA. In a murine wound infection model, this strategy markedly reduces bacterial burden and accelerates tissue regeneration, with a wound closure rate significantly higher than controls. Transcriptomic analysis reveals that M@HPBA regulates inflammatory and antioxidant pathways in MRSA-infected wounds, enhancing susceptibility to photothermal and ROS/metal ion killing. M@HPBA demonstrates broad-spectrum antibacterial activity and favorable biosafety. These findings establish a synergistic strategy integrating photothermal therapy, nanozyme catalysis, ion release, and antioxidant intervention, providing a translatable paradigm for precision antimicrobial therapy and infected wound management.