LncRNA HOXC-AS3 prevents chondrocyte senescence and osteoarthritis progression through miR-615-3p sponging and RRBP1 interaction

This study establishes lncRNA HOXC-AS3 as a key regulator of chondrocyte homeostasis that mitigates OA progression via dual mechanisms-miR-615-3p sponging and RRBP1 interaction-both of which maintain CIT expression. These findings advance the understanding of the molecular networks underlying OA pathogenesis and underscore HOXC-AS3 and its downstream signaling axis as promising therapeutic targets for OA intervention.