The expression of bcl-2 and Bax and its relationship between the apoptosis and/or proliferation

The amount of bcl-2 mRNA and Bax oncoprotein is increased obviously and the apoptosis and proliferation are active in the lung cancer. Bcl-2 and Bax, especially the ratio of bcl-2 and Bax play an important role in the apoptosis in the lung cancer. The expression of bcl-2 can prevent apoptosis while the expression of Bax induces apoptosis. bcl-2, Bax, apoptosis and PCNA can be used in the lung cancer molecular markers.