诱导多能干细胞
干细胞
胚胎干细胞
生物
神经干细胞
成体干细胞
体细胞
神经球
神经科学
细胞生物学
诱导干细胞
神经上皮细胞
遗传学
基因
作者
Bingchun Liu,Jiangzi Yuan,Ying Qiu
出处
期刊:Chin J Neurol
日期:2020-03-08
卷期号:53 (03): 217-220
标识
DOI:10.3760/cma.j.issn.1006-7876.2020.03.011
摘要
For decades, researchers have focused on building genetically and phenotypically stable neural stem cell lines designed to restore the irreversible loss of function of nerve tissue to meet clinical needs. Among them, stem cells that maintain their pluripotent state in adults have also become one of the research focuses. With the development of technologies such as induced pluripotent stem cells and direct differentiation of somatic cells into desired cell types, research methods based on the use of allogeneic neural stem cells derived from embryonic or fetal neural tissue have gradually become a thing of the past. This article will review the basic molecular mechanisms surrounding the maintenance of pluripotent states of stem cells and reprogrammed somatic cells, as well as experimental protocols for inducing neural stem cells.
Key words:
Adult stem cells; Pluripotent stem cells; Cell culture techniques; Nervous system
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