化学
重氮
碳化物
烷基化
光催化
催化作用
选择性
吡咯
药物化学
有机化学
组合化学
铑
作者
Łukasz Ciszewski,Jakub Durka,Dorota Gryko
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-08-19
卷期号:21 (17): 7028-7032
被引量:88
标识
DOI:10.1021/acs.orglett.9b02612
摘要
This article describes the photoalkylation of electron-rich aromatic compounds with diazo esters. C-2-alkylated indoles and pyrroles are obtained with good yields even though the photocatalyst loading is as low as 0.075 mol %. For EWG-substituted substrates, the addition of a catalytic amount of N,N-dimethyl-4-methoxyaniline is required. Both EWG-EWG- and EWG-EDG-substituted diazo esters are suitable as alkylating agents. The reaction selectivity and mechanistic experiments suggest that carbenes/carbenoid intermediates are not involved in the reaction pathway.
科研通智能强力驱动
Strongly Powered by AbleSci AI