Dyslipidemia in Type 1 Diabetes: A Masked Danger

Quantitative abnormalities of lipoproteins are present in T1D patients with poor glycemic control: increased triglycerides and LDL-cholesterol . T1D patients in optimal glycemic control have normal or slightly decreased levels of triglycerides and LDL-cholesterol , and normal or slightly increased HDL-cholesterol levels. All T1D patients show qualitative and functional abnormalities that are unrelated to hyperglycemia, and which are potentially atherogenic. The increased CV risk observed in T1D patients with normal or even increased levels of HDL-cholesterol might be partly explained by the functional abnormalities of HDL particles. The mechanisms responsible for the T1D dyslipidemia remain unclear, but the subcutaneous route of insulin administration, that is responsible for peripheral hyperinsulinemia, is likely to play a role. Type 1 diabetes (T1D) patients show lipid disorders which are likely to play a role in their increased cardiovascular (CV) disease risk. Quantitative abnormalities of lipoproteins are noted in T1D with poor glycemic control. In T1D with optimal glycemic control, triglycerides and LDL-cholesterol are normal or slightly decreased whereas HDL-cholesterol is normal or slightly increased. T1D patients, even with good glycemic control, show several qualitative and functional abnormalities of lipoproteins that are potentially atherogenic. An association between these abnormalities and CV disease risk has been reported in recent studies. Although the mechanisms underlying T1D dyslipidemia remain unclear, the subcutaneous route of insulin administration, that is responsible for peripheral hyperinsulinemia, is likely to be an important factor. Type 1 diabetes (T1D) patients show lipid disorders which are likely to play a role in their increased cardiovascular (CV) disease risk. Quantitative abnormalities of lipoproteins are noted in T1D with poor glycemic control. In T1D with optimal glycemic control, triglycerides and LDL-cholesterol are normal or slightly decreased whereas HDL-cholesterol is normal or slightly increased. T1D patients, even with good glycemic control, show several qualitative and functional abnormalities of lipoproteins that are potentially atherogenic. An association between these abnormalities and CV disease risk has been reported in recent studies. Although the mechanisms underlying T1D dyslipidemia remain unclear, the subcutaneous route of insulin administration, that is responsible for peripheral hyperinsulinemia, is likely to be an important factor.