抗菌剂
姜科
药物发现
次生代谢物
癌症
代谢物
生物
药理学
传统医学
医学
化学
生物信息学
生物化学
内科学
微生物学
根茎
基因
作者
Ammara Riaz,Azhar Rasul,Nazia Kanwal,Ghulam Hussain,Muhammad Ajmal Shah,Iqra Sarfraz,Rubab Ishfaq,Rabia Batool,Fariha Rukhsar,Şevki Adem
出处
期刊:Current Drug Metabolism
[Bentham Science]
日期:2020-12-01
卷期号:21 (14): 1079-1090
被引量:19
标识
DOI:10.2174/1389200221999200728144801
摘要
: Natural products, an infinite reserve of bioactive molecules, will continue to serve humans as an important source of therapeutic agents. Germacrone is a bioactive natural compound found in the traditional medicinal plants of family Zingiberaceae. This multifaceted chemical entity has become a point of focus during recent years due to its numerous pharmacological applications, e.g., anticancer, anti-inflammatory, antiviral, antioxidant, anti-adipogenic, anti-androgenic, antimicrobial, insecticidal, and neuroprotective. Germacrone is an effective inducer of cell cycle arrest and apoptosis in various cancers (breast, brain, liver, skin, prostate, gastric, and esophageal) via modulation of different cell signaling molecules and pathways involved in cancer proliferation. This is the first report highlighting the wide spectrum of pharmacological activities exhibited by germacrone. The reported data collected from various shreds of evidences recommend that this multifaceted compound could serve as a potential drug candidate in the near future.
科研通智能强力驱动
Strongly Powered by AbleSci AI