Enantioselective Arylcyanation of Styrenes viaCopper‐Catalyzed Radical Relay†

The first copper‐catalyzed enantioselective arylcyanation of styrenes has been developed using readily available anilines as aryl radical precursors under mild conditions, which enables easy access to chiral 2,3‐diaryl propionitriles with moderate to good enantioselectivities. This operationally straightforward reaction exhibits broad substrate scope and functional group tolerance. Notably, this method has been applied to the synthesis of chiral AIEgen as well as estrogen receptor‐β agonist ( R )‐diarylpropionitrile (DPN).