Effects of vitamin E and selenium on allergic rhinitis and asthma pathophysiology

Allergic diseases such as asthma and rhinitis are common health problems that affect hundreds of millions of people in the world. T helper 2 cytokines participate in the immune responses in these diseases. Vitamin E and selenium (Se) are supplementary factors which have immunomodulatory and antioxidant effects. The present study investigated the effects of vit E + Se administration on allergic symptoms in mice models of asthma and rhinitis. Mice were treated with vit E and Se, and the levels of IL-4, IL-5, IL-13, IL-25, IL-33, total IgE, and histamine were measured. Lung histopathology was also analyzed. Our results indicated that vit E could attenuate allergic rhinitis and asthma symptoms; nevertheless, treatment with Se alone was not effective in controlling allergic symptoms. We noticed reduced airway inflammation and constriction and mucus secretion in the mice, especially when vit E was used in combination with Se. Our result suggested that vit E, especially in combination with Se, could control allergic mediators and symptoms in rhinitis and asthma and reduce pulmonary inflammation and airway mucus secretion, helping to open obstructed bronchi.