Coinfection with HIV and hepatitis C virus (HCV) is a serious medical and social problem. As shown in some of the latest studies, if people with HIV are at about twice and those with HCV are at thrice the risk for death compared with healthy people, those with both infections are at almost 5 times the risk for it [1]! With that in mind the optimal choice of therapy regimens for patients with coinfection takes on particular and extremely important significance.