TRPV4型
化学
敌手
兴奋剂
药理学
瞬时受体电位通道
医学
受体
生物化学
作者
Brian G. Lawhorn,Edward J. Brnardic,David J. Behm
标识
DOI:10.1016/j.bmcl.2020.127022
摘要
TRPV4 is a ubiquitously expressed, non-selective cation channel activated by a range of stimuli including hypotonicity, temperature, pH, stretch and endogenous ligands. Agents that modulate TRPV4 are sought as potential therapeutics for the treatment of many diseases including osteoarthritis, respiratory illnesses, gastrointestinal disorders, pain and congestive heart failure. In recent years, significant advances in TRPV4 drug discovery have been realized as at least seven novel TRPV4 agonist or antagonist templates were reported and the first selective TRPV4 antagonist was evaluated in early clinical trials.
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