原位
费斯特共振能量转移
可视化
化学
过渡(遗传学)
生物物理学
纳米技术
材料科学
荧光
生物化学
物理
生物
光学
数据挖掘
计算机科学
基因
有机化学
作者
Mengyao Zhao,Jianbo Wang,Zuhai Lei,Lingfei Lu,Shangfeng Wang,Hongxin Zhang,Benhao Li,Fan Zhang
标识
DOI:10.1002/anie.202012021
摘要
Abstract Monitoring the pH in tumor lesions provides abundant physiological information. However, currently developed pH sensors only achieve sensitive detection in the settled response region around the pH transition point (pH t ). To realize tumor pH monitoring with high sensitivity within a wider response region, reported here are serial pH t adjustable sensors (pTAS) that simply regulate the component ratio of second near‐infrared (NIR‐II) emission aza‐BODIPY (NAB) donor and pH sensitive rhodamine‐based pre‐acceptor (NRh) in Förster resonance energy transfer system. Combining the pH response regions of pTAS, a twofold widened pH detection range (6.11–7.22) is obtained compared to the pH t settled sensor (6.38–6.94). With an adjustable pH t , in vivo tumor pH increase and decrease processes could be dynamically visualized through dual‐channel ratiometric bioimaging within the NIR‐II window, with a coefficient of variation under 1 % compared to the standard pH meter.
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