A new player in the beneficial effects of exercise on the aged brain

In a recent article in Science , Horowitz et al. identify glycosylphosphatidylinositol (GPI)-degrading enzyme Gpld1 as the most critical player in the blood that can transfer the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. They also demonstrate the importance of this liver-to-brain axis in ameliorating age-related regenerative and cognitive impairments. 1