壳聚糖
生物相容性
药物输送
多糖
组合化学
铵
聚合物
化学
离体
药品
纳米技术
材料科学
有机化学
体外
药理学
生物化学
生物
作者
Angela Fabiano,Denise Beconcini,Chiara Migone,Anna Maria Piras,Ylenia Zambito
摘要
As a natural polysaccharide, chitosan has good biocompatibility, biodegradability and biosecurity. The hydroxyl and amino groups present in its structure make it an extremely versatile and chemically modifiable material. In recent years, various synthetic strategies have been used to modify chitosan, mainly to solve the problem of its insolubility in neutral physiological fluids. Thus, derivatives with negative or positive fixed charge were synthesized and used to prepare innovative drug delivery systems. Positively charged conjugates showed improved properties compared to unmodified chitosan. In this review the main quaternary ammonium derivatives of chitosan will be considered, their preparation and their applications will be described to evaluate the impact of the positive fixed charge on the improvement of the properties of the drug delivery systems based on these polymers. Furthermore, the performances of the proposed systems resulting from in vitro and ex vivo experiments will be taken into consideration, with particular attention to cytotoxicity of systems, and their ability to promote drug absorption.
科研通智能强力驱动
Strongly Powered by AbleSci AI