星形胶质细胞
神经科学
信号
剧目
细胞内
钙
钙信号传导
钙显像
生物
化学
物理
细胞生物学
中枢神经系统
声学
有机化学
作者
Alexey Semyanov,Christian Henneberger,Amit Agarwal
标识
DOI:10.1038/s41583-020-0361-8
摘要
Astrocytes functionally interact with neurons and with other brain cells. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling that evolves in space and time within single astrocytes and across astrocytic networks. Decoding the physiological meaning of these dynamic changes in astrocytic Ca2+ activity has remained a major challenge. This Review describes experimental preparations and methods for recording and studying Ca2+ activity in astrocytes, focusing on the analysis of Ca2+ signalling events in single astrocytes and in astrocytic networks. The limitations of existing experimental approaches and ongoing technical and conceptual challenges in the interpretation of astrocytic Ca2+ events and their spatio-temporal patterns are also discussed. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling. Semyanov, Henneberger and Agarwal describe experimental preparations and methods for studying Ca2+ activity in astrocytes, their limitations and the ongoing technical and conceptual challenges in the interpretation of astrocytic Ca2+ events and their spatio-temporal patterns.
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