间充质干细胞
干细胞
间质细胞
再生医学
生物医学工程
材料科学
细胞外基质
再生(生物学)
骨髓
组织工程
细胞
医学
癌症研究
化学
细胞生物学
免疫学
生物化学
生物
作者
Eric Jacques,Katsuhiro Hosoyama,Brook Biniam,Çağla Eren Çimenci,Veronika Sedláková,Alexander J. Steeves,Fabio Variola,Darryl R. Davis,Duncan J. Stewart,Erik J. Suuronen,Emilio I. Alarcon
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2020-06-08
卷期号:6 (8): 4614-4622
被引量:13
标识
DOI:10.1021/acsbiomaterials.0c00245
摘要
As cell therapies emerged, it was quickly realized that pro-regenerative cells directly injected into injured tissue struggled within the inflammatory microenvironment. By using microencapsulation, i.e., encapsulating cells within polymeric biomaterials, they are henceforth protected from the harmful extracellular cues, while still being able to receive oxygen and nutrients and release secreted factors. Previous work showed that stem cells encapsulated within a biologically inert material (agarose) were able to significantly improve the function of the infarcted mouse heart. With the aim of using more bioresponsive microcapsules, we sought to develop an enzymatically degradable, type I collagen-based microcapsule for the intramyocardial delivery of bone marrow-derived mesenchymal stromal cells in a murine model of myocardial infarction.
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