Primary hepatic angiosarcoma

Primary hepatic angiosarcoma is a rare entity, representing only 4% \nof all the angiosarcomas of different origins1 and less than 1% of all \nhepatic malignancies.2 \nAccurate diagnosis of this tumour is difficult, especially if the \npatient has no history of exposure to specific carcinogens including \nthorotrast, arsenicals and vinyl chloride monomer.3 \nAngiosarcoma, a subtype of soft tissue sarcoma, is an aggressive \nmalignant disease deriving from endothelium, lymphatics or blood \nvessels. Some of the more common hepatic sarcomas are angiosarcoma, \nembryonal sarcoma, leiomyosarcoma, epithelioid hemangioendothelioma, \nfibrosarcoma and malignant fibrous histiocytoma.2 \nThe survival of hepatic angiosarcoma is very poor, which is attributable \nto its rapid progress, high recurrence rate and resistant to \ntraditional chemotherapy and radiotherapy.4 The survival of patients \nwith liver angiosarcoma is very poor with median survival of 6 \nmonths without treatment; after treatment, only 3% of patients were \nreported to live longer than 2 years