Iridium‐Catalyzed ortho‐C−H Amidation of Benzenesulfonamides with Sulfonyl Azides

Abstract We developed herein an iridium‐catalyzed direct C−H activation/ C−N bond formation reaction of benzenesulfonamides with sulfonyl azides. The amidation reaction provides a protocol for the synthesis of 2‐aminobenzesulfonamides in good to excellent yields. This strategy features a wide substrate scope, tolerates a broad range of functional groups under external oxidant‐free conditions and only releases molecular nitrogen as the sole by‐product. Moreover, the preliminary mechanism was investigated and the proposed reaction pathway was provided. magnified image