Progress in Difunctionalization of Alkenes

As an important kind of organic chemical reaction, difunctionalization of alkenes can not only synthesize multi-site reaction products effectively in one step, but also transform the starting material into other compounds that containing biological activity or drug activity. At the same time, it provides more methods for the construction of chemical structure diversity, so it is very important to develop the bifunctionalization of alkenes. In this paper, the bifunctionalization of various alkenes in recent 12 years is reviewed. It can be divided into three parts: copper-catalyzed difunctionalization of alkenes, other transition metal-catalyzed difunctionalization of alkenes, and non-metal-catalyzed difunctionalization of alkenes. The prospects of this reaction are also discussed.