Implantable multireservoir device with stimulus-responsive membrane for on-demand and pulsatile delivery of growth hormone

Significance We propose an implantable multireservoir device equipped with stimulus-responsive membrane to allow for on-demand and pulsatile drug delivery. The stimulus-responsive membrane is made of a thermosensitive polymer, POSS(MEO 2 MA-co-OEGMA), and photothermal nanoparticles of reduced graphene oxide. Each of the drug reservoirs is filled with the same amount of human growth hormone and capped with the stimulus-responsive membrane. Therefore, when implanted in living animals, the device herein can deliver drug reproducibly by rupturing a stimulus-responsive membrane only at the times of near-infrared irradiation applied from the outside body without showing complications.