高尿酸血症
排泄
Abcg2型
内科学
尿酸
内分泌学
痛风
病理生理学
医学
生物
运输机
ATP结合盒运输机
生物化学
基因
作者
Hirotaka Matsuo,Tomoyuki Tsunoda,Keiko Ooyama,Masayuki Sakiyama,Tsuyoshi Sogo,Tappei Takada,Akitoshi Nakashima,Akiyoshi Nakayama,Makoto Kikuchi,Toshihide Higashino,Kenji Wakai,Hiroshi Oda,Ryota Hokari,Hiroshi Suzuki,Kimiyoshi Ichida,Akio Inui,Shin Fujimori,Nariyoshi Shinomiya
摘要
To clarify the physiological and pathophysiological roles of intestinal urate excretion via ABCG2 in humans, we genotyped ABCG2 dysfunctional common variants, Q126X (rs72552713) and Q141K (rs2231142), in end-stage renal disease (hemodialysis) and acute gastroenteritis patients, respectively. ABCG2 dysfunction markedly increased serum uric acid (SUA) levels in 106 hemodialysis patients (P = 1.1 × 10(-4)), which demonstrated the physiological role of ABCG2 for intestinal urate excretion because their urate excretion almost depends on intestinal excretion via ABCG2. Also, ABCG2 dysfunction significantly elevated SUA in 67 acute gastroenteritis patients (P = 6.3 × 10(-3)) regardless of the degree of dehydration, which demonstrated the pathophysiological role of ABCG2 in acute gastroenteritis. These findings for the first time show ABCG2-mediated intestinal urate excretion in humans, and indicates the physiological and pathophysiological importance of intestinal epithelium as an excretion pathway besides an absorption pathway. Furthermore, increased SUA could be a useful marker not only for dehydration but also epithelial impairment of intestine.
科研通智能强力驱动
Strongly Powered by AbleSci AI