ADP核糖基化因子
转移
癌症研究
RAC1
癌症
胰腺癌
生物
细胞迁移
亚细胞定位
癌细胞
信号转导
细胞
医学
细胞生物学
内科学
细胞质
高尔基体
遗传学
作者
Rui Li,Cheng Peng,Xianzhe Zhang,Yuewei Wu,Shida Pan,Yong Xiao
出处
期刊:Life Sciences
[Elsevier]
日期:2017-08-01
卷期号:182: 80-84
被引量:73
标识
DOI:10.1016/j.lfs.2017.06.008
摘要
ADP-ribosylation factor 6 (Arf6), a member of small GTPases ADP-ribosylation factor (Arf) family, expresses widely in mammalian cells and mainly regulates the functions of membrane traffic and actin remodeling. Current studies indicated that the activation and high expression of Arf6 protein may be significantly correlated with the invasion and metastasis of several tumors, such as breast cancer, pancreatic cancer, lung cancer, etc. Meanwhile, the ability of tumor invasion and metastasis can be suppressed when Arf6 activity is blocked by the inhibitors or small-interfering RNAs of Arf6. To explore the precisely potential mechanisms between Arf6 and the process of tumor invasion, metastasis and proliferation, we concludes the functions and potential signaling pathways of Arf6 in tumor cells and provides an overview about clinical prospects of Arf6 in the screening, diagnosis, treatment and evaluation of prognosis of neoplasms.
科研通智能强力驱动
Strongly Powered by AbleSci AI