白藜芦醇
谷氨酸受体
红藻氨酸受体
癫痫
红藻氨酸
γ-氨基丁酸受体
药理学
兴奋毒性
海马结构
加巴能
海马体
癫痫发生
化学
抗惊厥药
神经科学
神经化学
受体
医学
神经学
生物化学
生物
AMPA受体
作者
Zhen Li,Zhuyan You,Min Li,Lei Pang,Jiwei Cheng,Liecheng Wang
标识
DOI:10.1007/s12264-017-0097-2
摘要
Accumulating evidence has suggested resveratrol as a promising drug candidate for the treatment of epilepsy. To validate this, we tested the protective effect of resveratrol on a kainic acid (KA)-induced epilepsy model in rats and investigated the underlying mechanism. We found that acute resveratrol application partially inhibited evoked epileptiform discharges in the hippocampal CA1 region. During acute, silent and chronic phases of epilepsy, the expression of hippocampal kainate glutamate receptor (GluK2) and the GABAA receptor alpha1 subunit (GABAAR-alpha1) was up-regulated and down-regulated, respectively. Resveratrol reversed these effects and induced an antiepileptic effect. Furthermore, in the chronic phase, resveratrol treatment inhibited the KA-induced increased glutamate/GABA ratio in the hippocampus. The antiepileptic effects of resveratrol may be partially attributed to the reduction of glutamate-induced excitotoxicity and the enhancement in GABAergic inhibition.
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