莱菔硫烷
萝卜硫苷
异硫氰酸盐
转移
癌症
转录因子
医学
化学
生物
生物信息学
芸苔属
药理学
癌症研究
硫代葡萄糖苷
内科学
生物化学
植物
基因
作者
Maria Russo,Carmela Spagnuolo,Gian Luigi Russo,Krystyna Skalicka-Woźniak,Maria Daglia,Eduardo Sobarzo‐Sánchez,Seyed Fazel Nabavi
标识
DOI:10.1080/10408398.2016.1259983
摘要
In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts against cancer at different levels, from development to progression, through pleiotropic effects. In this review, we discuss the available experimental and clinical data on the potential therapeutic role of sulforaphane against cancer. Its effects range from the protection of cells from DNA damage to the modulation of the cell cycle via pro-apoptotic, anti-angiogenesis and anti-metastasis activities. At molecular level, sulforaphane modulates cellular homeostasis via the activation of the transcription factor Nrf2. Although data from clinical studies are limited, sulforaphane remains a good candidate in the adjuvant therapy based on natural molecules against several types of cancer.
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