Application of Covalent Organic Framework-Based Electrochemical Biosensors in Biological Sample Detection

Covalent organic frameworks (COFs) are two-dimensional or three-dimensional organic crystalline materials with nanoscale structural order, which have structural advantages such as high periodicity and modifiability.Electrochemical biosensors based on COFs have the characteristics of ultra-sensitivity, strong specificity, and good repeatability, and have broad prospects in the detection of biological samples.The synthesis methods and strategies of COFs, the introduction and classification of electrochemical biosensors, and the application of COFs in electrochemical biosensing to detect biological samples are briefly summarized.Finally, the technical bottlenecks of COFs materials in the field of biosensing and their future development directions are summarized and discussed.