Role of Ubiquilin-2 in Proteostasis and Tau Aggregation in Tauopathies

Tauopathies are a group of neurologic disorders that include frontotemporal dementia (FTD) and Alzheimer's disease (AD), the most common forms of dementia ([Wang and Mandelkow, 2016][1]). A hallmark of tauopathies is the accumulation of toxic aggregates composed of hyperphosphorylated tau protein