血管生成
一氧化氮
衰老
内皮干细胞
功能(生物学)
医学
癌症研究
细胞生物学
生物
免疫学
内科学
生物化学
体外
作者
Jiaming Zhang,Cunrui Li,Yihua Zhang,Jianbing Wu,Zhangjian Huang
摘要
Abstract The decrease in angiogenesis that occurs with aging significantly contributes to the higher incidence and mortality of cardiovascular diseases among the elderly. This decline in angiogenesis becomes more pronounced with increasing age and is closely linked to abnormal function and senescence of endothelial cells. Enhancing angiogenesis in aging and targeting senescent endothelial cells have gained considerable attention. Nitric oxide (NO) has been thoroughly investigated for its function in regulating angiogenesis and is an important factor that can counteract endothelial cell senescence. This review summarizes the mechanisms of reduced angiogenesis during aging and therapeutic strategies targeting senescent cells. We also discuss the potential of combining the current approaches with NO in promoting angiogenesis in aging vessels.
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